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The Brown Laboratory

Exploring the neurobiological mechanisms that underlie the development and plasticity of the cerebral cortex.

Image by Milad Fakurian

Our Research

The Brown Lab studies cellular and systems plasticity in the healthy and diseased cerebral cortex. Using rodent models combined with in vivo multiphoton imaging of cortical blood flow and cellular structure and function the lab aims to understand how the different cellular building blocks of the mammalian brain respond to injury and disease.

Latest Publications

Our data show that in male mice, stimulating microglia with IFNγ promotes migration whereas inhibiting IFNγ receptor 1 signaling inhibits them. By contrast, female microglia were generally unaffected by these manipulations. These findings highlight the diversity of microglia migratory responses to injury, its dependence on sex and the signaling mechanisms that modulate this behavior.


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