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The Brown Laboratory

Exploring the neurobiological mechanisms that underlie the development and plasticity of the cerebral cortex.

Image by Milad Fakurian

Our Research

The Brown Lab studies cellular and systems plasticity in the healthy and diseased cerebral cortex. Using rodent models combined with in vivo multiphoton imaging of cortical blood flow and cellular structure and function the lab aims to understand how the different cellular building blocks of the mammalian brain respond to injury and disease.

Latest Publications

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes

Screening for circulating inflammatory cytokines revealed persistently high levels of interleukin-10 (IL-10) in diabetic mice. Chronic treatment of diabetic mice with IL-10 receptor neutralizing antibodies improved cerebral blood flow, increased capillary flux and diameter, downregulated haemostasis and cell adhesion-related gene expression, and reversed cognitive deficits. These data suggest that IL-10 signalling has an unexpected pathogenic role in cerebral microcirculatory defects and cognitive impairment associated with type 1 diabetes.

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